Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.
Identifieur interne : 002B30 ( Main/Exploration ); précédent : 002B29; suivant : 002B31Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.
Auteurs : Y P Wu [République populaire de Chine] ; Z H Liu ; R. Wei ; S D Pan ; N Y Mao ; B. Chen ; J J Han ; F S Zhang ; U. Holmskov ; Z L Xia ; P G De Groot ; K B M. Reid ; W B Xu ; G L SorensenSource :
- Scandinavian journal of immunology [ 1365-3083 ] ; 2009.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Immunoglobuline G (sang), Marqueurs biologiques (sang), Mâle, Protéine D associée au surfactant pulmonaire (sang), Protéines nucléocapside (immunologie), Protéines recombinantes (immunologie), RT-PCR, Sujet âgé, Syndrome respiratoire aigu sévère (immunologie), Test ELISA, Virus du SRAS (immunologie).
- MESH :
- immunologie : Protéines nucléocapside, Protéines recombinantes, Syndrome respiratoire aigu sévère, Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline G, Marqueurs biologiques, Protéine D associée au surfactant pulmonaire.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, RT-PCR, Sujet âgé, Test ELISA.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antibodies, Viral (blood), Biomarkers (blood), Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G (blood), Male, Middle Aged, Nucleocapsid Proteins (immunology), Pulmonary Surfactant-Associated Protein D (blood), Recombinant Proteins (immunology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology).
- MESH :
- chemical , blood : Antibodies, Viral, Biomarkers, Immunoglobulin G, Pulmonary Surfactant-Associated Protein D.
- chemical , immunology : Nucleocapsid Proteins, Recombinant Proteins.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Aged, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Pulmonary SP-D is a defence lectin promoting clearance of viral infections. SP-D is recognized to bind the S protein of SARS-CoV and enhance phagocytosis. Moreover, systemic SP-D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP-D, SARS-type pneumonia and the SARS-specific IgG response. Sixteen patients with SARS, 19 patients with community-acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP-D and anti-SARS-CoV N protein IgG were measured using ELISA. SP-D was significantly elevated in SARS-type pneumonia [median (95% CI), 453 (379-963) ng/ml versus controls 218 (160-362) ng/ml, P < 0.05] like in patients with CAP. SP-D significantly correlated with anti-SARS-CoV N protein IgG (r(2) = 0.5995, P = 0.02). The possible re-emergence of SARS or SARS-like infections suggests a need for minimal traumatic techniques for following the alveolar compartment, e.g. during testing of antivirals. We suggest that monitoring systemic SP-D may be useful in monitoring the alveolar integrity in SARS-type pneumonia. The significant correlation between plasma SP-D and anti-SARS-CoV-specific antibodies support the role for SP-D in interlinking innate and adaptive immune pathways.
DOI: 10.1111/j.1365-3083.2009.02245.x
PubMed: 19439011
Affiliations:
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Reid</name></author><author><name sortKey="Xu, W B" sort="Xu, W B" uniqKey="Xu W" first="W B" last="Xu">W B Xu</name></author><author><name sortKey="Sorensen, G L" sort="Sorensen, G L" uniqKey="Sorensen G" first="G L" last="Sorensen">G L Sorensen</name></author></analytic><series><title level="j">Scandinavian journal of immunology</title><idno type="eISSN">1365-3083</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antibodies, Viral (blood)</term><term>Biomarkers (blood)</term><term>Child</term><term>Child, Preschool</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Male</term><term>Middle Aged</term><term>Nucleocapsid Proteins (immunology)</term><term>Pulmonary Surfactant-Associated Protein D (blood)</term><term>Recombinant Proteins (immunology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Protéine D associée au surfactant pulmonaire (sang)</term><term>Protéines nucléocapside (immunologie)</term><term>Protéines recombinantes (immunologie)</term><term>RT-PCR</term><term>Sujet âgé</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Test ELISA</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Biomarkers</term><term>Immunoglobulin G</term><term>Pulmonary Surfactant-Associated Protein D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Nucleocapsid Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Protéines nucléocapside</term><term>Protéines recombinantes</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term><term>Marqueurs biologiques</term><term>Protéine D associée au surfactant pulmonaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>RT-PCR</term><term>Sujet âgé</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pulmonary SP-D is a defence lectin promoting clearance of viral infections. SP-D is recognized to bind the S protein of SARS-CoV and enhance phagocytosis. Moreover, systemic SP-D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP-D, SARS-type pneumonia and the SARS-specific IgG response. Sixteen patients with SARS, 19 patients with community-acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP-D and anti-SARS-CoV N protein IgG were measured using ELISA. SP-D was significantly elevated in SARS-type pneumonia [median (95% CI), 453 (379-963) ng/ml versus controls 218 (160-362) ng/ml, P < 0.05] like in patients with CAP. SP-D significantly correlated with anti-SARS-CoV N protein IgG (r(2) = 0.5995, P = 0.02). The possible re-emergence of SARS or SARS-like infections suggests a need for minimal traumatic techniques for following the alveolar compartment, e.g. during testing of antivirals. We suggest that monitoring systemic SP-D may be useful in monitoring the alveolar integrity in SARS-type pneumonia. The significant correlation between plasma SP-D and anti-SARS-CoV-specific antibodies support the role for SP-D in interlinking innate and adaptive immune pathways.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, B" sort="Chen, B" uniqKey="Chen B" first="B" last="Chen">B. Chen</name><name sortKey="De Groot, P G" sort="De Groot, P G" uniqKey="De Groot P" first="P G" last="De Groot">P G De Groot</name><name sortKey="Han, J J" sort="Han, J J" uniqKey="Han J" first="J J" last="Han">J J Han</name><name sortKey="Holmskov, U" sort="Holmskov, U" uniqKey="Holmskov U" first="U" last="Holmskov">U. Holmskov</name><name sortKey="Liu, Z H" sort="Liu, Z H" uniqKey="Liu Z" first="Z H" last="Liu">Z H Liu</name><name sortKey="Mao, N Y" sort="Mao, N Y" uniqKey="Mao N" first="N Y" last="Mao">N Y Mao</name><name sortKey="Pan, S D" sort="Pan, S D" uniqKey="Pan S" first="S D" last="Pan">S D Pan</name><name sortKey="Reid, K B M" sort="Reid, K B M" uniqKey="Reid K" first="K B M" last="Reid">K B M. Reid</name><name sortKey="Sorensen, G L" sort="Sorensen, G L" uniqKey="Sorensen G" first="G L" last="Sorensen">G L Sorensen</name><name sortKey="Wei, R" sort="Wei, R" uniqKey="Wei R" first="R" last="Wei">R. Wei</name><name sortKey="Xia, Z L" sort="Xia, Z L" uniqKey="Xia Z" first="Z L" last="Xia">Z L Xia</name><name sortKey="Xu, W B" sort="Xu, W B" uniqKey="Xu W" first="W B" last="Xu">W B Xu</name><name sortKey="Zhang, F S" sort="Zhang, F S" uniqKey="Zhang F" first="F S" last="Zhang">F S Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Y P" sort="Wu, Y P" uniqKey="Wu Y" first="Y P" last="Wu">Y P Wu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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